Ronald Koeman lifted the European Cup twice as a player but must now try to achieve Champions League success as a manager.
Europe’s top competition has provided plenty of heartache for Barca in the past couple of seasons, let’s hope for something different this time around.
Let’s see who might start:
There are unlikely to be too many changes in defence, although Koeman does have a few options to play with.
If Koeman does go with Junior then it’s possible Dest could replace Sergi Roberto on the opposite flank.
The rest of the defence looks like staying the same unless Koeman fancies giving Ronald Araujo another start and handing Gerard Pique a rest.
There could well be changes in midfield with Miralem Pjanic being tipped to make his first start for Barcelona since his move from Juventus.
The 30-year-old has only managed 28 minutes so far but has plenty of Champions League experience and could get the nod.
The big question then is who Koeman drops to the bench out of Sergio Busquets or Frenkie de Jong?
Koeman has plenty of big decisions to make in attack. Philippe Coutinho and Ansu Fati were rested last time out but could come straight back into the starting XI.
Antoine Griezmann’s place must be in jeopardy after a disappointing start to the season, while it might be a good idea to give Lionel Messi a rest too.
Pedri will be hoping to keep his place after an impressive full debut against Getafe, and Ousmane Dembele and Francisco Trincao are also in contention.
Possible XI: Neto; Roberto, Pique, Lenglet, Dest; Pjanic, Busquets; Trincao, Coutinho, Fati, Messi.
How do you think Barcelona should line up on Tuesday? Let us know your thoughts, predictions and teams in the comments below!